PROSPECTIVE BACTERIAL AND FUNGAL SOURCES OF HYALURONIC ACID: A REVIEW

.S. Shikina^a,b, R.A. Kovalevsky^a, A.I. Shirkovskaya^a, Ph.V. Toukach^a,c

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
^b M.V. Lomonosov Moscow State University, Department of Chemistry, Moscow, Russia
^c National Research University Higher School of Economics, Facultee of Chemistry, Moscow, Russia

KEYWORDS: Gram-positive bacteria; Hyaluronic acid; Microbial fermentation; Recombinant organism

Computational and Structural Biotechnology Journal, 2022, v.20, pp. 6214-6236

DOI: 10.1016/j.csbj.2022.11.013

The unique biological and rheological properties make hyaluronic acid a sought-after material for medicine and cosmetology. Due to very high purity requirements for hyaluronic acid in medical applications, the profitability of streptococcal fermentation is reduced. Production of hyaluronic acid by recombinant systems is considered a promising alternative. Variations in combinations of expressed genes and fermentation conditions alter the yield and molecular weight of produced hyaluronic acid. This review is devoted to the current state of hyaluronic acid production by recombinant bacterial and fungal organisms.

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