EXAMINING THE DIVERSITY OF STRUCTURAL MOTIFS IN FUNGAL GLYCOME

Ph.V. Toukach^a,b, K.S. Egorova^a

^aN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia ^bNational Research University Higher School of Economics, Moscow, Russia

KEYWORDS: fungi, bacteria, protista, glycome, carbohydrate, glycan, diversity, CSDB

Computational and Structural Biotechnology Journal, 2022, v.20, pp. 5466-5476

DOI: 10.1016/j.csbj.2022.09.040

In this paper, we present the results of a systematic statistical analysis of the fungal glycome in comparison with the prokaryotic and protistal glycomes as described in the scientific literature and presented in the Carbohydrate Structure Database (CSDB). The monomeric and dimeric compositions of glycans, their non-carbohydrate modifications, glycosidic linkages, sizes of structures, branching degree and net charge are assessed. The obtained information can help elucidating carbohydrate molecular markers for various fungal classes which, in its turn, can be demanded for the development of diagnostic tools and carbohydrate-based vaccines against pathogenic fungi. It can also be useful for revealing specific glycosyltransferases active in a particular fungal species.

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Science: CSDB

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