STRUCTURE AND GENE CLUSTER OF THE CAPSULAR POLYSACCHARIDE OF ACINETOBACTER BAUMANNII K223

A.V. Filatov^a, A.M. Shpirt^a, A.V. Perepelov^a, A.S. Dmitrenok^a, M.M. Shneider^b, V.A. Avdeeva^c, P.V. Toukach^a, Y.A. Knirel^a

^aN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia
^bM.M. Shemyakin & Y.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
^cState Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia

KEYWORDS: Acinetobacter baumannii; Ñapsular polysaccharide; K locus; Structure; Gene cluster

Carbohydrate Research, 2026, v. 563, ID 109846

DOI: 10.1016/j.carres.2026.109846

Structure of the Acinetobacter baumannii strain MAR22-475 classified to KL223 type capsular polysaccharide (CPS) was established by component analyses, Smith degradation as well as ¹H and ¹³C NMR spectroscopy, including two-dimensional homonuclear 1Í,1Í COSY, TOCSY, ROESY and heteronuclear 1Í,13C HSQC and HMBC experiments. The K223 CPS is composed of branched tetrasaccharide K-units containing two D-Glñp residues, and one residue each of D-GlcpNAc and D-Galp. The following structure of the tetrasaccharide repeating unit of the CPS was established:

b-D-Glcp-(1
          |
          3
           -6)-a-D-Glcp-(1-4)-a-D-Galp-(1-3)-a-D-GlcpNAc-(1-

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